Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folic Acid
400 mcg
100%
Vitamin B-12 (as Cyanocobalamin)
5 mg (5,000 mcg)
83,333%
Top Medical Research Studies
9
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Read More
7
We examined the effects of Secholex, an anion-exchange gel, on high cholesterol in 46 patients with severe hyperlipoproteinemia over various studies. The results revealed that Secholex effectively lowered cholesterol levels, achieving a 15% reduction after the first year and 13% during the second year. While it was less effective than cholestyramine in increasing bile acid excretion, many patients preferred Secholex. However, it’s important to note that a third of patients experienced limited reductions in cholesterol, indicating varying responses.
Read More
9
We explored the effects of partial ileal bypass (PIB) on cholesterol levels in a small group of young adults with hyperlipidemia. After the surgical procedure, participants received vitamin B12 injections twice monthly.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Read More
Most Useful Reviews
9
Numbness relieved
1 people found this helpful
For neuralgia, I suffered from constant numbness in my arms and hands, possibly due to my back or neck. After trying high-concentration mecobalamin for a few weeks, the numbness subsided, providing real relief. I have finished the course, but will repurchase if symptoms return.
Read More
6
Strong bodily effect
2 people found this helpful
Mumtaz—The quality and ingredients are excellent, and the quantity is generous. It aids the nervous system and has a sweet berry flavour. My mother took it for a week, but after testing, her cholesterol levels were elevated, leading her to discontinue use. Nonetheless, it had a potent effect on her body.
Read More
7.5
High-quality results
1 people found this helpful
I bought this for my mother for the fourth time, and the results are consistently excellent. I recommend it for those with vitamin B12 deficiency. It’s high-quality, with enough folic acid for two months, providing the necessary energy. The packaging is suitable, and the flavour is appealing. It enhances metabolism and supports the nervous system. If you experience B12 deficiency, which may cause numbness in extremities, this is worth trying.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.5
- All Researches
9
We explored how a specific dietary supplement that includes Vitamin B12 affects cholesterol levels in individuals with moderate high cholesterol. In our study, 80 participants were split into a treatment group and a control group.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
Read More
9
We focused on whether white button mushrooms could help lower cholesterol levels and blood sugar in rats. In our study, we found that after three weeks of the mushroom powder, diabetic rats showed significant drops in glucose and triglyceride levels.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Furthermore, in hypercholesterolemic rats, a four-week treatment led to impressive reductions in total cholesterol and LDL cholesterol. Overall, these findings suggest that white button mushrooms may have beneficial effects on cholesterol and blood sugar management, at least in rat models.
Read More
9
We explored the effects of partial ileal bypass (PIB) on cholesterol levels in a small group of young adults with hyperlipidemia. After the surgical procedure, participants received vitamin B12 injections twice monthly.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Impressively, total plasma cholesterol levels decreased significantly three months after surgery and remained lower after one year. However, while PIB helped normalize cholesterol, it didn't completely prevent the progression of atherosclerosis in some patients. This indicates that while B12 treatment benefited cholesterol levels, it wasn't a cure-all for other cardiovascular issues we studied.
Read More
8
We explored the effects of vitamins B12, B6, and folic acid on cholesterol and homocysteine levels in 24 male patients with high triglycerides and cholesterol issues. Over 120 days, patients took specific doses of these vitamins while researchers measured their lipid and homocysteine levels at various intervals.
While we saw a notable decrease in homocysteine levels and triglycerides, high-density lipoprotein (HDL) did increase slightly. However, overall cholesterol levels did not significantly change.
This suggests that while vitamin B supplementation can affect certain lipids and lower homocysteine, it may not drastically alter cholesterol levels in these patients.
While we saw a notable decrease in homocysteine levels and triglycerides, high-density lipoprotein (HDL) did increase slightly. However, overall cholesterol levels did not significantly change.
This suggests that while vitamin B supplementation can affect certain lipids and lower homocysteine, it may not drastically alter cholesterol levels in these patients.
Read More
8
We explored how adding plant sterols to orange juice can impact cholesterol levels in mildly hypercholesterolemic individuals. In this study, 72 healthy participants enjoyed either regular orange juice or a fortified version for eight weeks.
Those drinking the fortified juice saw a decrease in total cholesterol by 7.2%, LDL cholesterol by 12.4%, and non-HDL cholesterol by 7.8%. However, we found no changes in HDL cholesterol or triglyceride levels. The results suggest that plant sterol-fortified orange juice can be a simple addition to a cholesterol-lowering diet.
Those drinking the fortified juice saw a decrease in total cholesterol by 7.2%, LDL cholesterol by 12.4%, and non-HDL cholesterol by 7.8%. However, we found no changes in HDL cholesterol or triglyceride levels. The results suggest that plant sterol-fortified orange juice can be a simple addition to a cholesterol-lowering diet.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Numbness relieved
1 people found this helpful
For neuralgia, I suffered from constant numbness in my arms and hands, possibly due to my back or neck. After trying high-concentration mecobalamin for a few weeks, the numbness subsided, providing real relief. I have finished the course, but will repurchase if symptoms return.
Read More
6
Strong bodily effect
2 people found this helpful
Mumtaz—The quality and ingredients are excellent, and the quantity is generous. It aids the nervous system and has a sweet berry flavour. My mother took it for a week, but after testing, her cholesterol levels were elevated, leading her to discontinue use. Nonetheless, it had a potent effect on her body.
Read More
7.5
High-quality results
1 people found this helpful
I bought this for my mother for the fourth time, and the results are consistently excellent. I recommend it for those with vitamin B12 deficiency. It’s high-quality, with enough folic acid for two months, providing the necessary energy. The packaging is suitable, and the flavour is appealing. It enhances metabolism and supports the nervous system. If you experience B12 deficiency, which may cause numbness in extremities, this is worth trying.
Read More
Frequently Asked Questions
9
Numbness relieved
1 people found this helpful
For neuralgia, I suffered from constant numbness in my arms and hands, possibly due to my back or neck. After trying high-concentration mecobalamin for a few weeks, the numbness subsided, providing real relief. I have finished the course, but will repurchase if symptoms return.
7.5
High-quality results
1 people found this helpful
I bought this for my mother for the fourth time, and the results are consistently excellent. I recommend it for those with vitamin B12 deficiency. It’s high-quality, with enough folic acid for two months, providing the necessary energy. The packaging is suitable, and the flavour is appealing. It enhances metabolism and supports the nervous system. If you experience B12 deficiency, which may cause numbness in extremities, this is worth trying.
6
Strong bodily effect
2 people found this helpful
Mumtaz—The quality and ingredients are excellent, and the quantity is generous. It aids the nervous system and has a sweet berry flavour. My mother took it for a week, but after testing, her cholesterol levels were elevated, leading her to discontinue use. Nonetheless, it had a potent effect on her body.
7
We examined a multi-ingredient supplement (MIS) featuring red yeast rice and omega-3 fatty acids to see how it impacts cholesterol levels in patients without cardiovascular disease.
In our pilot study involving 19 participants, we found that the MIS significantly reduced total cholesterol and LDL cholesterol levels. While those on the combined regimen of MIS and omega-3 saw a drop in triglycerides, the change wasn't significant, likely due to the small participant group.
Overall, the MIS shows promise in helping with cholesterol management and may improve patient compliance.
In our pilot study involving 19 participants, we found that the MIS significantly reduced total cholesterol and LDL cholesterol levels. While those on the combined regimen of MIS and omega-3 saw a drop in triglycerides, the change wasn't significant, likely due to the small participant group.
Overall, the MIS shows promise in helping with cholesterol management and may improve patient compliance.
9
We explored how a specific dietary supplement that includes Vitamin B12 affects cholesterol levels in individuals with moderate high cholesterol. In our study, 80 participants were split into a treatment group and a control group.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
After 6 months, the group taking the supplement experienced a notable drop in total cholesterol (TC) and improvements in other cholesterol types, while the control group showed no significant changes outside of TC reduction.
This suggests that, while a healthy diet and exercise can help, the addition of such supplements, including Vitamin B12, may enhance cholesterol management more effectively.
8
We explored the effects of vitamins B12, B6, and folic acid on cholesterol and homocysteine levels in 24 male patients with high triglycerides and cholesterol issues. Over 120 days, patients took specific doses of these vitamins while researchers measured their lipid and homocysteine levels at various intervals.
While we saw a notable decrease in homocysteine levels and triglycerides, high-density lipoprotein (HDL) did increase slightly. However, overall cholesterol levels did not significantly change.
This suggests that while vitamin B supplementation can affect certain lipids and lower homocysteine, it may not drastically alter cholesterol levels in these patients.
While we saw a notable decrease in homocysteine levels and triglycerides, high-density lipoprotein (HDL) did increase slightly. However, overall cholesterol levels did not significantly change.
This suggests that while vitamin B supplementation can affect certain lipids and lower homocysteine, it may not drastically alter cholesterol levels in these patients.
8
We explored how adding plant sterols to orange juice can impact cholesterol levels in mildly hypercholesterolemic individuals. In this study, 72 healthy participants enjoyed either regular orange juice or a fortified version for eight weeks.
Those drinking the fortified juice saw a decrease in total cholesterol by 7.2%, LDL cholesterol by 12.4%, and non-HDL cholesterol by 7.8%. However, we found no changes in HDL cholesterol or triglyceride levels. The results suggest that plant sterol-fortified orange juice can be a simple addition to a cholesterol-lowering diet.
Those drinking the fortified juice saw a decrease in total cholesterol by 7.2%, LDL cholesterol by 12.4%, and non-HDL cholesterol by 7.8%. However, we found no changes in HDL cholesterol or triglyceride levels. The results suggest that plant sterol-fortified orange juice can be a simple addition to a cholesterol-lowering diet.
7
We examined the effects of Secholex, an anion-exchange gel, on high cholesterol in 46 patients with severe hyperlipoproteinemia over various studies. The results revealed that Secholex effectively lowered cholesterol levels, achieving a 15% reduction after the first year and 13% during the second year. While it was less effective than cholestyramine in increasing bile acid excretion, many patients preferred Secholex. However, it’s important to note that a third of patients experienced limited reductions in cholesterol, indicating varying responses.
References
- Wright N, Wilson L, Smith M, Duncan B, McHugh P. The BROAD study: A randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes. Nutr Diabetes. 2017;7:e256. doi:10.1038/nutd.2017.3
- Hobbs T, Caso R, McMahon D, Nymark M. A novel, multi-ingredient supplement to manage elevated blood lipids in patients with no evidence of cardiovascular disease: a pilot study. Altern Ther Health Med. 2014;20:18.
- Lombardo F, Lunghi R, Pallotti F, Palumbo A, Senofonte G, et al. Effects of a dietary supplement on cholesterol in subjects with moderate hypercholesterolemia. Clin Ter. 2013;164:e147. doi:10.7417/CT.2013.1556
- Garaiova I, Muchová J, Nagyová Z, Mišľanová C, Oravec S, et al. Effect of a plant sterol, fish oil and B vitamin combination on cardiovascular risk factors in hypercholesterolemic children and adolescents: a pilot study. Nutr J. 2013;12:7. doi:10.1186/1475-2891-12-7
- Jeong SC, Jeong YT, Yang BK, Islam R, Koyyalamudi SR, et al. White button mushroom (Agaricus bisporus) lowers blood glucose and cholesterol levels in diabetic and hypercholesterolemic rats. Nutr Res. 2010;30:49. doi:10.1016/j.nutres.2009.12.003
- Morón de Salim AR, Garcés Pasamontes A. [Effect of the supplementation of vitamins B12, B6 and folic acid on homocysteine and plasmatic lipids in patients with hyperlipoproteinemic secondary type IV]. Arch Latinoam Nutr. 2005;55:28.
- Devaraj S, Jialal I, Vega-López S. Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. Arterioscler Thromb Vasc Biol. 2004;24:e25.
- MacMahon M, Kirkpatrick C, Cummings CE, Clayton A, Robinson PJ, et al. A pilot study with simvastatin and folic acid/vitamin B12 in preparation for the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH). Nutr Metab Cardiovasc Dis. 2000;10:195.
- Defraigne JO, Pirenne J, Swinnen JC, Honore P, Jacquet N, et al. [Value and limits of bypassing the distal ileum in the treatment of hypercholesterolemia]. J Chir (Paris). 1990;127:76.
- Nikkila EA, Miettinen TA, Lanner A. Treatment of hypercholesterolemia with Secholex. A long-term clinical trial and comparison with cholestyramine. Atherosclerosis. 1976;24:407.
